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The genetics of exceptional human longevity.

Thomas Perls1, Louis M Kunkel, Annibale A Puca

  • 1Geriatrics Section, Boston Medical Center, Boston University Medical School, Massachusetts 02118, USA.

Journal of the American Geriatrics Society
|May 25, 2002
PubMed
Summary

Genetics influence average lifespan and health, but exceptional longevity involves specific genetic factors. These longevity genes likely impact aging mechanisms and disease resistance, offering a survival advantage.

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Area of Science:

  • Genetics
  • Gerontology
  • Longevity Research

Background:

  • Distinguishes between genetics of aging and exceptional longevity.
  • Average genetic variations support reaching octogenarian years.
  • Poor health habits can negate genetic endowment, reducing life expectancy.

Purpose of the Study:

  • Investigate genetic factors in exceptional longevity.
  • Understand the role of genetics in extending lifespan beyond average.
  • Identify genetic variations contributing to disease resistance and longevity.

Main Methods:

  • Review of twin studies on aging.
  • Analysis of lifespan experiments in model organisms.
  • Population and molecular genetic studies of centenarian families.

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Main Results:

  • Genetic factors are crucial for exceptional longevity.
  • These factors likely influence fundamental aging processes.
  • Longevity may involve lacking disease predisposition and possessing disease resistance genes.

Conclusions:

  • Exceptional longevity is significantly influenced by specific genetic factors.
  • These genetic variations impact aging mechanisms and susceptibility to age-related diseases.
  • Future research is expected to elucidate these key longevity-enabling genes.