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Intestinal microvillous atrophy in a patient with Down syndrome and aganglionic megacolon
Miguel A Martínez1, Anastasio Serrano Egea, Javier Manzanares López
1Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain. mmartinezg@hdoc.insalud.es
Ultrastructural Pathology
|May 25, 2002
Abstract:
Intestinal microvillous disorders are an uncommon cause of severe diarrhea, with very poor prognosis. The authors report the case of a female infant with Down syndrome, aganglionic megacolon, severe diarrhea, and jejunal biopsy with ultrastructural changes consistent with microvillous atrophy. The patient condition improved after a colostomy performed in the setting of the treatment of Hirschprung disease.