Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein synthesis in the dendrite.

Shao Jun Tang1, Erin M Schuman

  • 1Howard Hughes Medical Institute, Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA. schumane@caltech.edu

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|May 25, 2002
PubMed
Summary

Synaptic protein synthesis, where messenger RNA (mRNA) is translated locally, is a key mechanism for neural plasticity. Further research is needed to understand its precise functions in synaptogenesis and neural plasticity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes.

Science (New York, N.Y.)·2026
Same author

An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution.

Nature communications·2025
Same author

Cell type-specific in vivo proteomes with a multicopy mutant methionyl tRNA synthetase mouse line.

Lab animal·2025
Same author

Neuronal processes contain the essential components for the late steps of ribosome biogenesis.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Understanding the molecular diversity of synapses.

Nature reviews. Neuroscience·2024
Same author

The proteomic landscape of synaptic diversity across brain regions and cell types.

Cell·2023

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Many synaptic proteins are crucial for synaptic activity and neural plasticity.
  • The precise mechanisms for targeting these proteins to synapses are not fully understood.
  • Synaptic protein synthesis, involving local mRNA translation, is a proposed mechanism.

Purpose of the Study:

  • To investigate the role and mechanisms of synaptic protein synthesis.
  • To elucidate the physiological functions of synaptic protein synthesis in synaptogenesis and neural plasticity.

Main Methods:

  • Detection of mRNA species in neuronal dendrites.
  • Analysis of polyribosome localization in synaptic regions.
  • Experimental approaches to study synaptic protein synthesis in a physiological context.

Related Experiment Videos

Main Results:

  • An increasing number of mRNA species have been identified in dendrites.
  • Information on the physiological context of specific synaptic protein synthesis is limited.
  • The physiological functions of synaptic protein synthesis in synaptogenesis and neural plasticity require further demonstration.

Conclusions:

  • Synaptic protein synthesis offers a local source for synaptic proteins.
  • Understanding the mechanisms and functions of synaptic protein synthesis is vital for elucidating neural plasticity.
  • Further experiments are necessary to confirm the role of synaptic protein synthesis in neural processes.