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[Fibrates].

Nobuhiro Yamada1

  • 1Institute of Clinical Medicine, University of Tsukuba.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 28, 2002
PubMed
Summary
This summary is machine-generated.

Fibrates, by activating peroxisome proliferating activated alpha (PPAR alpha), effectively lower triglycerides and raise HDL cholesterol. These actions reduce cardiovascular events in patients with dyslipidemia.

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Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Molecular Biology

Context:

  • Fibrates are established lipid-lowering agents.
  • Their primary mechanism involves activating the peroxisome proliferating activated alpha (PPAR alpha) nuclear receptor.
  • Understanding their full impact on vascular biology is ongoing.

Purpose:

  • To elucidate the molecular mechanisms by which fibrates influence lipid metabolism and vascular biology.
  • To highlight the role of PPAR alpha activation in mediating these effects.
  • To summarize clinical evidence on fibrate efficacy in cardiovascular event reduction.

Summary:

  • Fibrates activate PPAR alpha, modulating genes critical for lipoprotein metabolism (e.g., lipoprotein lipase, apo AI, apo AII, apo CIII).

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  • This activation lowers atherogenic remnant lipoproteins and elevates anti-atherogenic HDL cholesterol.
  • Fibrates also impact vascular inflammation, contributing to their cardioprotective effects.

    • Impact:

    • Fibrates significantly reduce cardiovascular events in patients with hypertriglyceridemia and low HDL cholesterol.
    • They offer a therapeutic strategy for managing dyslipidemia and preventing atherosclerosis.
    • The findings underscore the importance of PPAR alpha as a therapeutic target in cardiovascular disease.