Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Anti-hyperlipidemic agents].

Makoto Kinoshita1

  • 1Department of Internal Medicine, Teikyo University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 28, 2002
PubMed
Summary

Several non-statin and non-fibrate medications, including resins, probucol, nicotinic acid, and eicosapentaenoic acid, effectively manage hyperlipidemia and prevent cardiovascular events. These drugs are often combined for severe cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Validation of a Method for the Simultaneous Determination of Pesticide Residues in Soybeans and Brown Rice by GC-MS/MS Using a Multi-Functional SPE-Based Sample Preparation Procedure].

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·2026
Same author

A hypofunctional PREX1 variant (p.Y191C) leads to neurodevelopmental abnormalities and epilepsy by attenuating RAC1 signaling.

Scientific reports·2026
Same author

Environmental enrichment is associated with enhanced novel object recognition performance and an increased proportion of smooth endoplasmic reticulum-containing spines in the dentate gyrus of Septin3<sup>-/-</sup> mice.

Molecular brain·2026
Same author

Genetics and immunity in neuromyelitis optica spectrum disorder.

The Lancet. Neurology·2026
Same author

Impact of Preoperative Malnutrition and Sarcopenia on Clinical Outcomes After Transcatheter Aortic Valve Replacement.

Circulation reports·2026
Same author

Headache prevalence and types in multiple sclerosis and related neuroimmunological diseases: A multicenter study.

Cephalalgia : an international journal of headache·2026

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Lipid Metabolism

Context:

  • Hyperlipidemia poses a significant risk for cardiovascular diseases, including coronary heart disease (CHD).
  • While statins and fibrates are primary treatments, other pharmacological agents are crucial for managing lipid disorders.
  • Percutaneous coronary intervention (PCI) can lead to restenosis, a complication requiring specific therapeutic interventions.

Purpose:

  • To review and summarize the therapeutic applications of non-statin and non-fibrate drugs in managing hyperlipidemia.
  • To highlight the roles of specific agents like resins, probucol, nicotinic acid, and eicosapentaenoic acid in lipid management and cardiovascular event prevention.
  • To discuss the potential for combination therapies in treating severe hyperlipidemia.

Summary:

  • Resins are effective for hypercholesterolemia and coronary heart disease (CHD) prevention.
  • Probucol treats hypercholesterolemia and may prevent restenosis after percutaneous coronary intervention (PCI).
  • Nicotinic acid addresses hypertriglyceridemia and hypercholesterolemia, aiding CHD prevention.
  • Eicosapentaenoic acid is beneficial for hypertriglyceridemia and inhibits platelet aggregation.
  • These agents, alongside statins and fibrates, form combination therapies for severe hyperlipidemia.

Impact:

  • Provides a comprehensive overview of alternative and adjunctive therapies for hyperlipidemia.
  • Informs clinical practice regarding the use of diverse medications for cardiovascular risk reduction.
  • Highlights the importance of tailored pharmacological approaches for managing complex lipid profiles.

Related Experiment Videos