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Glucocorticoids in adipocytes stimulate visceral obesity
1Department of Nutritional Sciences and Toxicology, University of California, Berkeley 94720-3104, USA.
Nutrition Reviews
|May 28, 2002
Abstract:
The enzyme 11beta hydroxysteroid dehydrogenase-1 (11beta HSD-1) regenerates active glucocorticoids from inactive glucocorticoids. When over-expressed in adipose tissue, this enzyme was shown to promote increased visceral adipose levels. The resulting visceral obesity was associated with insulin-resistant diabetes and dyslipidemia. Increased adipocyte 11beta HSD-1 is a possible cause of visceral obesity in humans.