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Related Experiment Videos

Sinus inflammation associated with contralateral inverted papilloma.

Richard R Orlandi1, Adam Rubin, Jeffrey E Terrell

  • 1Division of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City 84132, USA.

American Journal of Rhinology
|May 28, 2002
PubMed
Summary

Unilateral inverted papilloma (IP) is linked to inflammation in the opposite sinuses, more so than other sinonasal tumors. This suggests inflammation may play a role in IP development.

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Area of Science:

  • Otolaryngology
  • Radiology
  • Pathology

Background:

  • Inverted papilloma (IP) is a sinonasal tumor with unclear etiology.
  • Previous research suggests IP may have an inflammatory component.

Purpose of the Study:

  • To investigate the association between unilateral inverted papilloma (IP) and contralateral sinus inflammation using computerized tomography (CT).
  • To compare the degree of contralateral inflammation in IP patients with those having other sinonasal tumors and healthy controls.

Main Methods:

  • Retrospective analysis of CT scans from patients with unilateral IP, other sinonasal tumors, and healthy controls.
  • Utilized a modified Lund-Mackay scoring system to assess sinus inflammation on CT.
  • Compared CT findings of contralateral sinuses across the three study groups.

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Main Results:

  • A statistically significant difference in contralateral sinus inflammation was observed across the groups (p = 0.010).
  • Patients with unilateral IP showed higher contralateral sinus inflammation scores compared to those with other sinonasal tumors (p = 0.06).
  • Both IP and other tumor groups had significantly higher inflammation scores than normal controls (p < 0.02).

Conclusions:

  • Unilateral inverted papillomas are associated with contralateral sinus inflammation detected by CT.
  • The degree of contralateral inflammation in IP cases exceeds that seen with other sinonasal tumors.
  • Findings suggest inflammation may be involved in the pathogenesis of inverted papilloma, warranting further investigation.