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Updated: Aug 9, 2026
Reproductive Techniques for Ovarian Monitoring and Control in Amphibians
Published on: May 12, 2019
Environmental estrogens and reproductive biology in amphibians
G Mosconi1, O Carnevali, M F Franzoni
1Dipartimento Scienze Morfologiche e Biochimiche Comparate, Università di Camerino, Camerino, Italy.
Abstract:
In this paper, the effects of an estrogenic compound, 4-nonyl-phenol (NP), on the amphibians Rana esculenta and Triturus carnifex are described together with those on sexual differentiation in Xenopus laevis. NP increased plasma vitellogenin in male frogs and newts in a dose-related manner; moreover, inhibitory effects on gonadotropin and prolactin (PRL) secretion by pituitary were found together with an elevation of plasma androgens. NP treatment also caused a remarkable increase in number of prolactin-immunolabeled cells, suggesting that xenoestrogen might induce, at least in the newt pituitary, a PRL accumulation possibly due to a reduction of the hormone release. In addition, both NP and bisphenol A caused feminization by increasing the percentage of female phenotypes in X. laevis, and the in vivo effects were more pronounced than those of estradiol-17beta.
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