Related Experiment Video
Updated: Oct 1, 2026
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
The effects of hormone replacement therapy on endothelial function in women with Turner's syndrome
N Norman Chan1, Patrick Vallance, Helen M Colhoun
1Centre for Clinical Pharmacology, EURODIAB, Department of Epidemiology and Public Health, University College London, London, UK. nnkachan@aol.com
Objectives:
To examine the effect of hormone replacement therapy (HRT) on endothelial function of forearm resistance vessels in women with Turner's syndrome.
Design:
Subjects were studied on three occasions: on their usual HRT (study 1), then after 6 weeks off HRT (study 2) and finally after a further 6 weeks on HRT (study 3).
Patients:
Seven young women with Turner's syndrome were studied.
Measurements:
Forearm blood flow in response to intrabrachial infusion of bradykinin, 10, 30, 100 pmol/min (endothelium-dependent vasodilator), glyceryl trinitrate, 4, 8, 16 nmol/min (GTN; endothelium-independent vasodilator), noradrenaline, 60, 120, 240 pmol/min (NA, alpha-adrenergic receptor agonist) and NG-monomethyl-l-arginine, 1, 2, 4 micromol/min (L-NMMA; NO synthase inhibitor) was assessed by bilateral venous plethysmography.
Results:
The vasodilator response to bradykinin, expressed as the within-subject mean difference in area under the dose-response curve between study 2 and study 1, was significantly diminished (-744.2 +/- 287.2, P = 0.04) but improved 6 weeks after HRT recommencement. However, there was no significant change in response to GTN (between study 2 and study 1, 189.5 +/- 247.8, P = 0.47). The vasoconstrictor response to L-NMMA was also diminished in study 2 when compared to study 1 (-100.4 +/- 35.4, P = 0.039) and was restored after HRT was recommenced (between study 3 and study 2, 117.5 +/- 69.3, P = 0.17) whereas there was no significant difference in response to NA between study 2 and study 1 (76.7 +/- 50.6, P = 0.18) or study 3 and study 2 (-70.8 +/- 71.1, P = 0.38).
Conclusions:
HRT improves endothelial function in women with Turner's syndrome.
Related Concept Videos
01:22Target Cell Response to Hormones
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
01:28Menopause
01:18Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
02:03Hormonal Regulation