Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of human alphaherpesvirus microRNA expression in latently infected human trigeminal ganglia.

Journal of virology·2009
Same author

Simian varicella virus induces apoptosis in monkey kidney cells by the intrinsic pathway and involves downregulation of bcl-2 expression.

Journal of virology·2009
Same author

Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency.

Neurologic clinics·2008
Same author

CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome.

Journal of neuroimmunology·2008
Same author

Prevention of shingles: safety and efficacy of live zoster vaccine.

Therapeutics and clinical risk management·2008
Same author

Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts.

Journal of medical virology·2008

Related Experiment Video

Updated: Dec 21, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.2K

A search for virus in multiple sclerosis.

Donald H Gilden1

  • 1Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA. don.gilden@uchsc.edu

Hybridoma and Hybridomics
|May 29, 2002
PubMed
Summary
This summary is machine-generated.

Scientific breakthroughs rely on accumulated data. This research revisits early experiments suggesting viruses cause neurological diseases, proposing new molecular techniques to identify a potential MS virus and its demyelination mechanism.

More Related Videos

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

5.1K
An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
06:36

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Published on: February 5, 2015

7.4K

Related Experiment Videos

Last Updated: Dec 21, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

1.2K
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

5.1K
An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
06:36

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Published on: February 5, 2015

7.4K

Area of Science:

  • Neuroscience
  • Virology
  • Immunology

Background:

  • Historical experiments in the 1960s indicated that certain chronic neurological diseases are transmissible, potentially viral.
  • Dr. Hilary Koprowski's team investigated a viral etiology for Multiple Sclerosis (MS) in the 1970s, analyzing MS brain cells for viral infection.
  • Early investigations using 1970s technology did not detect a virus in MS brain tissue.

Discussion:

  • Modern molecular biology techniques offer enhanced sensitivity for detecting viruses compared to methods used in the 1970s.
  • Revisiting MS research with current technology could validate earlier hypotheses about viral causation.
  • Identifying the specific virus responsible for MS is crucial for understanding disease mechanisms.

Key Insights:

  • The transmissibility of neurological diseases was established in the 1960s.
  • Past research into a viral cause for MS did not yield conclusive results due to technological limitations.
  • Current molecular biology tools may enable the detection of a causative MS virus.

Outlook:

  • Future studies utilizing advanced molecular techniques could confirm a viral etiology for MS.
  • Identifying the MS-causing virus may elucidate the mechanisms of demyelination.
  • This research holds the potential to revolutionize our understanding and treatment of Multiple Sclerosis.