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Updated: Oct 1, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair
Armin Blesch1, Paul Lu, Mark H Tuszynski
1Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0626, USA. ablesch@ucsd.edu
Abstract:
Several experimental strategies have been employed to minimize tissue damage and to enhance axonal growth and regeneration after spinal cord injury. The transplantation of suitable cell types to provide an axonal growth substrate and the application of growth factors have been shown to augment morphological and sometimes functional recovery. In this review we discuss the use of neural stem cell transplants and neurotrophic factor delivery by gene therapy to improve axonal regeneration in animal models of spinal cord injury.
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