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Published on: August 1, 2015
Electrochemical and peroxidase oxidation study of N'-hydroxyguanidine derivatives as NO donors
Tingwei Cai1, Ming Xian, Peng George Wang
1Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Abstract:
The electrochemical properties of a series of N-substituted-N'-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E(ox1) values were from 0.51 to 0.62V, while the E(ox2) values were from 1.14 to 1.81V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N'-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence of H(2)O(2).
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