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Synthesis and cytotoxicity of 2alpha-amido docetaxel analogues
Wei-Shuo Fang1, Ying Liu, Hong-Yan Liu
1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, PR China. wfang@imm.ac.cn
Bioorganic & Medicinal Chemistry Letters
|May 29, 2002
Abstract:
Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and D-seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines.