Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cycloartane triterpenoids from Guarea macrophylla.

João Henrique G Lago1, Nídia F Roque

  • 1Instituto de Química, Universidade de São Paulo, C.P. 26077, CEP 05599-970, São Paulo, SP, Brazil. joaolago@iq.usp.br

Phytochemistry
|May 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Multidimensional Evaluation of Sakuranetin against <i>Schistosoma mansoni</i>: From Drug-Likeness to <i>In Vivo</i> Efficacy.

ACS omega·2026
Same author

Cooperative effects of natural acetylenic acetogenins fromPorcelia macrocarpaon lipid packing and mechanical stability of Langmuir monolayers as protozoan membrane models.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Mitochondria-mediated apoptosis induced by acetogenins from Porcelia macrocarpa (Annonaceae) in K562 chronic myeloid leukemia cells.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

The Metabolome of the <i>Ocotea</i> spp.: From Biosynthetic Aspects to Bioactive Chemical Scaffolds by Integrating the Genus Chemical Database (<i>Ocotea</i>DB).

Journal of natural products·2026
Same author

Differential lethal action of octyl and oct-4E-enyl p-nitrobenzoates in Leishmania spp. - a mechanistic study.

Chemico-biological interactions·2026
Same author

Spathulenol, a Sesquiterpene from <i>Guarea macrophylla</i>, Displays Potent and Selective <i>Anthelmintic</i> Activity against <i>Angiostrongylus cantonensis</i>.

ACS omega·2026

Researchers isolated nine cycloartane triterpenoids from Guarea macrophylla leaves, including two novel compounds. Structural elucidation utilized advanced nuclear magnetic resonance (NMR) spectroscopy techniques.

Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Organic Chemistry

Background:

  • Guarea macrophylla is a plant species known for its potential bioactive compounds.
  • Triterpenoids are a diverse class of natural products with various biological activities.
  • Cycloartane triterpenoids represent a specific subclass with unique structural features.

Purpose of the Study:

  • To isolate and characterize cycloartane triterpenoids from the leaves of Guarea macrophylla.
  • To identify and elucidate the structures of novel triterpenoid derivatives.
  • To contribute to the understanding of the chemical constituents of Guarea macrophylla.

Main Methods:

  • Extraction and isolation of compounds from plant material.
  • Structure elucidation using comprehensive spectroscopic methods.

Related Experiment Videos

  • Nuclear Magnetic Resonance (NMR) spectroscopy, including 1H, 13C, HOMOCOSY, HMQC, and HMBC analyses.

    • Main Results:

    • Isolation of nine cycloartane triterpenoids.
    • Identification of two new cycloartane triterpenoid derivatives: 22,25-dihydroxy-cycloart-23E-en-3-one and 24-methylenecycloartane-3 beta,22-diol.
    • Confirmation of structures through detailed spectral data interpretation.

    Conclusions:

    • The chemical investigation of Guarea macrophylla leaves yielded a diverse array of cycloartane triterpenoids.
    • The discovery of new derivatives expands the known chemical diversity within this class of compounds.
    • The study provides valuable structural information on natural products from Guarea macrophylla.