Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Global high-throughput screens for cellular function.

Robert S Hauptschein1, Brenda K Eustace, Daniel G Jay

  • 1Department of Physiology, Tufts University School of Medicine, Boston, Mass., 02111, USA.

Experimental Hematology
|May 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of eHsp90 in Extracellular Matrix Remodeling, Tumor Invasiveness, and Metastasis.

Cancers·2024
Same author

Extracellular Hsp90 Binds to and Aligns Collagen-1 to Enhance Breast Cancer Cell Invasiveness.

Cancers·2023
Same author

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia.

The New England journal of medicine·2020
Same author

Hepatocyte Stress Increases Expression of Yes-Associated Protein and Transcriptional Coactivator With PDZ-Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis.

Hepatology (Baltimore, Md.)·2019
Same author

Metabolic response of lung cancer cells to radiation in a paper-based 3D cell culture system.

Biomaterials·2016
Same author

Emerging Roles of Extracellular Hsp90 in Cancer.

Advances in cancer research·2016
Same journal

Integrin alpha 4 inhibition prolongs the survival of NSG mice engrafted with CD19-negative post-CART19 relapsed B-ALL.

Experimental hematology·2026
Same journal

RNA Binding Protein PCBP1 Functions in the Endothelial-to-Hematopoietic Transition During Hematopoietic Stem Cell Formation.

Experimental hematology·2026
Same journal

Image-enabled cell sorting permits prospective isolation of primitive hematopoietic stem cell subsets with distinct functional potential.

Experimental hematology·2026
Same journal

Inhibition of MLLT1 Limits Growth of KMT2A::AFF1 Leukemias Without Killing Healthy Hematopoietic Stem Cells.

Experimental hematology·2026
Same journal

Adaptive Immune Remodeling in Sickle Cell Disease: Linking Hemolysis-Driven Inflammation to Immune Dysfunction.

Experimental hematology·2026
Same journal

Cytotoxic and Genotoxic Stress Transiently Increase the Contribution of Platelet-Biased Hematopoietic Stem Cells to Platelet Production.

Experimental hematology·2026
See all related articles

High-throughput cellular function assessment methods are crucial for scientists. This survey reviews technologies for rapid target validation, aiding drug discovery from genomics and proteomics data.

Area of Science:

  • Biotechnology
  • Cell Biology
  • Genomics

Background:

  • Academic and pharmaceutical researchers require efficient methods for assessing cellular function.
  • High-throughput screening is essential for validating numerous disease-related molecular targets.

Purpose of the Study:

  • To survey existing technologies for high-throughput cellular function assessment.
  • To discuss the applications, promise, and limitations of these methods.

Main Methods:

  • Review of systematic inactivation strategies.
  • Analysis of high-throughput cell-based assays.
  • Survey of current technologies and their applications.

Main Results:

  • Identification of key technologies enabling rapid target validation.

Related Experiment Videos

  • Discussion of the potential of these methods in the context of emerging molecular targets.
  • Evaluation of the limitations in addressing the vast number of candidate molecules.

    • Conclusions:

    • High-throughput cellular assessment technologies are vital for modern biological and pharmaceutical research.
    • These methods offer significant promise for accelerating drug discovery and understanding disease mechanisms.
    • Further development is needed to fully address the challenges posed by large-scale omics data.