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Propofol reduces spinal motor neuron excitability in humans
Manabu Kakinohana1, Tatsuya Fuchigami, Seiya Nakamura
1Division of Anesthesia, Okinawa Prefectural Miyako Hospital, Okinawa, Japan. mnb-shk@ryukyu.ne.jp
Anesthesia and Analgesia
|May 29, 2002
Abstract
Implications:
We investigated in humans whether changes in spinal motor neuron excitability correlate with the predicted propofol concentration (Cpt) achieved by a target-controlled infusion system. Propofol suppressed F-wave persistence in a Cpt-dependent manner, indicating that propofol depresses spinal motor neuron excitability at clinically relevant concentrations.