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Updated: Oct 1, 2026

Xenopus laevis as a Model to Identify Translation Impairment
Published on: September 27, 2015
A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation
Amanda Charlesworth1, John A Ridge, Leslie A King
1Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, 4301 West Markham Street Slot 814, Little Rock, AR 72205, USA.
Abstract:
Progression through vertebrate oocyte maturation requires that pre-existing, maternally derived mRNAs be translated in a strict temporal order. The mechanism that controls the timing of oocyte mRNA translation is unknown. In this study we show that the early translational induction of the mRNA encoding the Mos proto-oncogene is mediated through a novel regulatory element within the 3' untranslated region of the Mos mRNA. This novel element is responsive to the MAP kinase signaling pathway and is distinct from the late acting, cdc2-responsive, cytoplasmic polyadenylation element. Our findings suggest that the timing of maternal mRNA translation is controlled through signal transduction pathways targeting distinct 3' UTR mRNA elements.
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