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Updated: Aug 7, 2026
08:50
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
[Celiac disease and spontaneous abortion]
1Istituto di Clinica Ginecologica e Ostetrica A, Università degli Studi, Verona, Italy.
Minerva Ginecologica
|May 29, 2002
Summary
Celiac disease, often presenting atypically, is linked to recurrent spontaneous abortions in women. Screening for celiac disease is recommended for women with a history of multiple abortions to identify potential subclinical cases.
Area of Science:
- Gastroenterology
- Gynecology
- Immunology
Context:
- Celiac disease (CD) diagnosis is often delayed due to its varied clinical presentations, including silent or atypical forms.
- Gynecological issues such as infertility and recurrent abortions are increasingly recognized in women with CD.
- The prevalence of CD is estimated at 1/170-200, yet a significant number of adult cases remain undiagnosed.
Purpose:
- To investigate the association between celiac disease and recurrent spontaneous abortion.
- To determine if women experiencing recurrent miscarriages may exhibit subclinical or atypical celiac disease.
Summary:
- A study of 184 women found 2.7% (5 women) diagnosed with celiac disease via immunological screening (anti-endomysial antibodies) and biopsy.
- Of the diagnosed women, 2.1% had a history of spontaneous abortion, while 0.5% were from the control group.
- This suggests a potential link between celiac disease and recurrent pregnancy loss.
Impact:
- Highlights the need for broader celiac disease screening in at-risk populations.
- Recommends considering celiac disease testing for women with a history of multiple abortions.
- Emphasizes the importance of recognizing atypical presentations of celiac disease in gynecological practice.
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