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Related Experiment Videos

ErbB2 activation of ESX gene expression.

Richard M Neve1, Bauke Ylstra, Chuan-Hsiung Chang

  • 1Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.

Oncogene
|May 29, 2002
PubMed
Summary

The Ets-related gene (ESX) is upregulated in some breast cancers and its transcription is controlled by ErbB receptor signaling. ErbB2 signaling directly influences ESX expression, suggesting ESX is a downstream mediator in ErbB2-driven breast cancer.

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The Ets multigene family plays critical roles in cellular processes including development, differentiation, gene expression, and cancer.
  • The Ets-related gene (ESX) has been identified as upregulated in a subset of breast tumors and cell lines, prompting investigation into its role in mammary gland development and malignancy.

Purpose of the Study:

  • To elucidate the transcriptional regulation of ESX in epithelial breast cancer cells.
  • To investigate the relationship between ESX expression and ErbB receptor signaling, particularly ErbB2, in breast cancer.

Main Methods:

  • Utilized transient reporter assays with the ESX promoter to study transcriptional regulation.
  • Analyzed ESX and ErbB2 transcript levels in cell lines and 45 primary ductal breast cancers.

Related Experiment Videos

  • Investigated the effects of ErbB2 expression and inhibition on ESX promoter activity and protein levels.

    • Main Results:

    • ESX transcription is regulated by ErbB receptor signaling.
    • ESX transcript expression significantly correlates with ErbB2 transcript levels in both cell lines and primary breast cancers.
    • ErbB2 expression upregulates ESX promoter activity, while ErbB2 inhibition decreases ESX promoter activity and protein levels.

    Conclusions:

    • The ESX promoter is a transcriptional target of ErbB2 signaling.
    • ESX expression may act as a downstream mediator of ErbB2 signaling pathways in breast cancer.
    • ESX could play a role in ErbB2-induced gene expression and breast tumorigenesis.