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Attributable mortality of Stenotrophomonas maltophilia bacteremia
Esin Senol1, Jeffrey DesJardin, Paul C Stark
1Department of Medicine, Division of Geographic Medicine and Infectious Diseases, New England Medical Center and Tufts University School of Medicine, Boston, MA, USA. mass@bir.net.tr
Abstract:
A systematic evaluation of the attributable mortality of Stenotrophomonas maltophilia bacteremia was undertaken in a matched, retrospective, case-control study. We determined the attributable mortality rate (26.7%) and mortality risk ratio (an 8-fold increase) of S. maltophilia bacteremia. The attributable mortality rate for S. maltophilia bacteremia is similar to the attributable mortality rate for other nosocomial bloodstream infections.
Insights
Stenotrophomonas maltophilia bacteremia significantly increases mortality risk by 8-fold. This finding highlights the serious threat of this infection, comparable to other hospital-acquired bloodstream infections.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Epidemiology
Background:
- Stenotrophomonas maltophilia is an opportunistic pathogen frequently associated with nosocomial infections.
- Bacteremia caused by S. maltophilia poses a significant clinical challenge due to its intrinsic resistance to multiple antibiotics.
- Understanding the mortality attributable to S. maltophilia bacteremia is crucial for risk assessment and infection control.
Purpose of the Study:
- To systematically evaluate the attributable mortality associated with Stenotrophomonas maltophilia bacteremia.
- To quantify the mortality risk ratio for patients with S. maltophilia bacteremia compared to matched controls.
- To compare the mortality impact of S. maltophilia bacteremia with other nosocomial bloodstream infections.
Main Methods:
- A matched, retrospective, case-control study design was employed.
- Cases were defined as patients with S. maltophilia bacteremia.
- Controls were matched to cases based on relevant clinical factors to isolate the impact of S. maltophilia.
Main Results:
- The attributable mortality rate for S. maltophilia bacteremia was determined to be 26.7%.
- S. maltophilia bacteremia was associated with an 8-fold increase in the mortality risk ratio.
- The mortality impact of S. maltophilia bacteremia was found to be similar to that of other common nosocomial bloodstream infections.
Conclusions:
- Stenotrophomonas maltophilia bacteremia is associated with substantial attributable mortality.
- The findings underscore the clinical significance of S. maltophilia as a cause of severe infection.
- Effective infection control strategies are essential to mitigate the risks associated with this pathogen in healthcare settings.