Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrochemical sensor for electrochemically inactive beta-D(+)-glucose using alpha-cyclodextrin template molecules.

Shin-Jung Choi1, Bo-Geum Choi, Su-Moon Park

  • 1Department of Chemistry, Pohang University of Science and Technology, Kyungbuk, Korea.

Analytical Chemistry
|May 30, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mutation Analysis of Synthetic DNA Barcodes in a Fission Yeast Gene Deletion Library by Sanger Sequencing.

Genomics & informatics·2018
Same author

Development of galvanostatic Fourier transform electrochemical impedance spectroscopy.

Analytical chemistry·2013
Same author

DNA hybridization sensors based on electrochemical impedance spectroscopy as a detection tool.

Sensors (Basel, Switzerland)·2012
Same author

Reduced graphene oxide (rGO)-wrapped fullerene (C₆₀) wires.

ACS nano·2011
Same author

Multifunctional conjugated polymers with main-chain donors and side-chain acceptors for dye sensitized solar cells (DSSCs) and organic photovoltaic cells (OPVs).

Macromolecular rapid communications·2011
Same author

Novel quinoxaline-based organic sensitizers for dye-sensitized solar cells.

Organic letters·2011

This study presents a novel electrochemical sensor using alpha-cyclodextrin self-assembled monolayers to detect electrochemically inactive compounds like glucose. The sensor indirectly measures glucose by observing changes in ferrocene oxidation current.

Area of Science:

  • Electrochemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Electrochemical sensors typically require analytes to be electroactive.
  • Detecting electrochemically inactive compounds like glucose poses a significant challenge.
  • Self-assembled monolayers (SAMs) offer a platform for modifying electrode surfaces.

Purpose of the Study:

  • To develop a novel electrochemical sensor for detecting electrochemically inactive organic compounds.
  • To utilize a self-assembled monolayer of thiolated alpha-cyclodextrin (alpha-CD) on a gold surface.
  • To establish a method for indirect analyte detection via competitive displacement.

Main Methods:

  • Formation of a SAM of thiolated alpha-cyclodextrin on a gold electrode surface.

Related Experiment Videos

  • Utilizing ferrocene as a capture molecule within the SAM.
  • Measuring the decrease in ferrocene oxidation current due to displacement by the target analyte (e.g., glucose).

    • Main Results:

    • The electrochemical sensor successfully detected electrochemically inactive glucose.
    • The decrease in ferrocene oxidation current was directly proportional to glucose concentration.
    • Glucose was analyzed up to approximately 0.80 mM, a fraction of physiological levels.

    Conclusions:

    • The developed SAM-based electrochemical sensor provides a viable method for detecting electrochemically inactive compounds.
    • The sensor operates on a principle of competitive displacement, offering a new sensing strategy.
    • Further optimization could lead to sensors for a wider range of analytes at physiological concentrations.