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Updated: Oct 1, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Interaction with simian Hck tyrosine kinase reveals convergent evolution of the Nef protein from simian and human
C Picard1, A Greenway, G Holloway
1Institut de Cancérologie et d'Immunologie de Marseille, U119 INSERM, 27 boulevard Leï Roure, 13009, France.
Abstract:
Simian and human immunodeficiency virus type 1 (SIV and HIV-1) Nef proteins are thought to use different molecular surfaces to mediate the protein-protein interactions required for their otherwise similar functions. This genetically separable function suggests convergent evolution of primate lentiviruses and/or structural differences between human and nonhuman primate cellular target proteins. However, such comparative molecular analyses have not been undertaken so far using the respective natural host-derived cellular targets. We cloned simian Src family kinase Hck and analyzed structurally and biochemically its interaction with SIV Nef.
