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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
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Elevated C-reactive protein in patients with obstructive sleep apnea.
Abu S M Shamsuzzaman1, Mikolaj Winnicki, Paola Lanfranchi
1Mayo Clinic Rochester, Rochester, MN 59905, USA.
Circulation
|May 30, 2002
Summary
Obstructive sleep apnea (OSA) is linked to higher C-reactive protein (CRP) levels, a marker of inflammation and cardiovascular risk. Higher CRP indicates greater OSA severity.
Area of Science:
- Cardiology
- Sleep Medicine
- Inflammation Research
Background:
- Obstructive sleep apnea (OSA) is increasingly associated with cardiovascular and cerebrovascular diseases.
- Inflammatory processes in OSA may contribute to cardiovascular morbidity.
- This study investigated the link between OSA and C-reactive protein (CRP) levels.
Purpose of the Study:
- To test the hypothesis that patients with OSA exhibit elevated plasma CRP levels.
- To explore the relationship between OSA severity and CRP levels.
Main Methods:
- Studied 22 newly diagnosed OSA patients without other diseases or medications.
- Compared CRP levels in OSA patients with 20 age- and BMI-matched controls without occult OSA.
- Utilized multivariate analysis to assess independent associations.
Main Results:
- Plasma CRP levels were significantly higher in OSA patients compared to controls (median 0.33 vs. 0.09 mg/dL).
- Elevated CRP levels were independently associated with OSA severity (P=0.032).
Conclusions:
- Obstructive sleep apnea is associated with elevated C-reactive protein (CRP) levels.
- CRP serves as a marker for inflammation and cardiovascular risk in OSA patients.
- The severity of OSA is directly proportional to CRP levels.
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