[Serum lipoproteins in elderly patients with cerebrovascular pathology]

Contents of 7 serum lipoprotein (LP) fractions both native and after their incubation under 37 degrees C during 24 h in the patients with atherosclerosis and hypertension discirculatory encephalopathy were investigated by a gradient gel-electrophoresis method. Two groups of patients in the age of 30-59 in the first group and 61-73 in the second one were examined. It was found that for the age interval examined in native serum of the patients with atherosclerosis and hypertension similar changes of LP contents were observed. These changes were expressed a increasing apoA- and decreasing apoB-containing LP fractions as compared with the control. After the temperature incubation of healthy persons serum the amount of LDL increases and amount of HDL3 declines. The latter is a result of LP lypolysis and etherification normal processes. On the base of the data obtained we may suppose that in the patients with hypertension these processes also have some aged peculiarities, although less intensive as compared with the healthy persons. In contrast to the latter after the temperature incubation of serum (in vitro) in the patients with atherosclerosis there were no any statistically significant changes of any LP fractions contents that may evidence about depression of LP transformation in the isolated serum in such patients.