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Do neuroleptics alter the cerebral intracellular pH value in schizophrenics?-a (31)P-MRS study on three different
Stefan Riehemann1, Gabriele Hübner, Stefan Smesny
1Department of Psychiatry, University of Jena, Philosophenweg 3, D-07740, Jena, Germany. Stefan.Riehemann@iof.fraunhofer.de
Psychiatry Research
|May 31, 2002
Abstract:
The intracellular pH value has a profound influence on cerebral metabolism. Thus, inadequate pH control may intensify local metabolic deficits. To investigate the influence of neuroleptics on cerebral intracellular pH, we retrospectively evaluated the findings from three independent phosphorous-31 magnetic resonance spectroscopy ((31)P-MRS) studies on schizophrenic patients. A total sample of 72 patients and 32 healthy controls was investigated. A modified pH value was found only in those schizophrenic patients treated with the atypical neuroleptic clozapine.