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Related Experiment Videos

Lipid-based formulations for intestinal lymphatic delivery.

Caitriona M O'Driscoll1

  • 1Department of Pharmaceutics and Pharmaceutical Technology, University of Dublin, Trinity College, Ireland. kdrscoll@tcd.ie

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|May 31, 2002
PubMed
Summary

Lipid-based vehicles show limited intestinal lymphatic transport, but recent studies reveal over 50% can be achieved in fed states, sparking renewed interest in lymphatic targeting strategies.

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Area of Science:

  • Pharmacokinetics and Drug Delivery
  • Gastrointestinal Physiology
  • Formulation Science

Background:

  • Intestinal lymphatic transport is crucial for delivering lipophilic drugs.
  • Current lipid-based vehicles show variable and often disappointing lymphatic transport rates (20-30%).
  • Direct comparison of studies is difficult due to variations in vehicle design, drug properties, and experimental methods.

Purpose of the Study:

  • To review recent literature on lipid-based vehicles for intestinal lymphatic transport.
  • To analyze the successes and limitations of current formulation approaches.
  • To identify areas for future research in lymphatic drug targeting.

Main Methods:

  • Literature review of publications utilizing lipid-based vehicles for intestinal lymphatic transport.

Related Experiment Videos

  • Analysis of reported lymphatic transport percentages for various compounds.
  • Examination of factors influencing drug transport, including vehicle design and physiological state.

    • Main Results:

    • Lipid-based vehicles have achieved maximum lymphatic transport of approximately 20-30% for highly lipophilic drugs.
    • Recent studies show potential for >50% lymphatic transport in fed states, particularly for halofantrine.
    • Key factors influencing lymphatic transport remain incompletely understood.

    Conclusions:

    • Significant improvements in intestinal lymphatic transport are possible, especially in the postprandial state.
    • Further research is needed to fully elucidate the mechanisms governing lymphatic transport.
    • Optimizing lipid-based formulations holds promise for enhanced lymphatic drug targeting.