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Related Experiment Videos

Current "corrected" calcium concept challenged.

R W Pain, K M Rowland, P J Phillips

    British Medical Journal
    |December 13, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Individual serum calcium levels vary significantly due to albumin binding. Using personalized regression coefficients, not averages, is crucial for accurate calcium concentration correction. A tourniquet test can help determine this individual factor.

    Area of Science:

    • Clinical Biochemistry
    • Internal Medicine

    Background:

    • Serum calcium concentration is commonly "corrected" for variations in serum albumin.
    • However, there is wide individual variation in calcium bound per gram of albumin.

    Purpose of the Study:

    • To determine individual regression coefficients for serum calcium on serum albumin concentration.
    • To assess the validity of using average regression coefficients for calcium correction.

    Main Methods:

    • Determined individual regression coefficients in 62 subjects (25 patients, 37 from literature).
    • Calculated the 95 percentile range and median value for these coefficients.
    • Proposed a tourniquet test for determining individual coefficients.

    Main Results:

    Related Experiment Videos

    • The 95 percentile range for calcium bound per gram of albumin was 0.007-0.053 mmol/g (median 0.025 mmol/g).
    • This wide range indicates that using an average regression coefficient for "correcting" serum calcium is not valid.

    Conclusions:

    • Individual regression coefficients, not average ones, must be used for accurate serum calcium correction.
    • A tourniquet test may offer a simple method for obtaining individual coefficients.
    • Establishing appropriate reference ranges for corrected calcium requires individual correction factors.