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Related Experiment Videos

Decrease of core body temperature in mice by dehydroepiandrosterone.

Fernando Catalina1, Leon Milewich, William Frawley

  • 1Departments of Pathology, Obstetrics and Gynecology, and Academic Computing Services, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9072, USA.

Experimental Biology and Medicine (Maywood, N.J.)
|May 31, 2002
PubMed
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Dehydroepiandrosterone (DHEA) effectively lowers body temperature in mice, independent of food intake reduction or effects on serotonin and dopamine pathways. This hypothermic effect appears to be a direct action of DHEA on the body.

Area of Science:

  • Endocrinology
  • Neuroscience
  • Physiology

Background:

  • Dietary dehydroepiandrosterone (DHEA) is known to reduce food intake in mice, with this effect influenced by genetics.
  • Both DHEA and food restriction can prevent or treat certain diseases and exert other biological effects.
  • DHEA's impact on body temperature and its underlying mechanisms are not fully understood.

Purpose of the Study:

  • To investigate the effect of dehydroepiandrosterone (DHEA) on body temperature in mice.
  • To determine if DHEA-induced hypothermia is related to its effects on food intake, neurotransmitters, or its metabolites.
  • To explore the direct action of DHEA on temperature-regulating sites.

Main Methods:

  • Mice were fed DHEA or pair-fed (food restricted) for 8 weeks to assess body temperature changes.

Related Experiment Videos

  • DHEA was administered intraperitoneally in varying doses to evaluate dose-dependent hypothermic effects.
  • Mice were treated with neurotransmitter-modulating agents (haloperidol, 5,7-dihydroxytryptamine, ritanserin) before DHEA injection.
  • The hypothermic effects of DHEA metabolites and analogs were compared to DHEA.

    • Main Results:

    • DHEA was more effective than food restriction alone in inducing hypothermia.
    • Intraperitoneal DHEA injection caused a dose-dependent hypothermic effect, with a nadir at 1-2 hours.
    • Neurotransmitter antagonists/inhibitors enhanced DHEA's hypothermic effects, suggesting DHEA does not act via serotonin or dopamine.
    • DHEA metabolites were less effective, while a DHEA analog was as active, indicating direct action.

    Conclusions:

    • DHEA induces hypothermia in mice through a mechanism independent of food intake reduction.
    • The hypothermic effect of DHEA is not mediated by serotonin or dopamine pathways.
    • DHEA appears to act directly on central temperature-regulating sites, rather than through its downstream steroid metabolites.