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Updated: Oct 1, 2026

Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats
Published on: October 1, 2007
A case of cutaneous delayed-type allergy to oral dexamethasone and to betamethasone
Eleonora Nucera1, Alessandro Buonomo, Emanuela Pollastrini
1Department of Allergology, Policlinico 'A. Gemelli', Università Cattolica del Sacro Cuore, Roma, Italia.
Abstract:
Corticosteroids are drugs that may cause allergic contact dermatitis, but systemic allergic reactions to these drugs are rare. A 29-year-old man developed a maculopapular rash during an oral therapy with betamethasone. Patch tests demonstrated a delayed-type allergy to dexamethasone, betamethasone and fluocortolone. Oral, intramuscular or topical provocation tests with other corticosteroids - deflazacort, hydrocortisone, methylprednisolone, fluticasone dipropionate, triamcinolone and prednisone - were all negative. This demonstrates that a patient with a systemic allergy to a group of corticosteroids can tolerate those of other groups.
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