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Related Experiment Videos

A Pacinian corpuscle in the human bladder lamina propria.

D N Landon1, O J Wiseman

  • 1Department of Neuropathology, Institute of Neurology University College London and National Hospital for Neurology and Neurosurgery, UK. D.Landon@ion.ucl.ac.uk

Journal of Neurocytology
|May 31, 2002
PubMed
Summary

Researchers discovered a complex Pacinian corpuscle in the human urinary bladder lining. This encapsulated nerve ending, found in the lamina propria, is the first reported instance in an adult bladder.

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Area of Science:

  • Urology
  • Neuroanatomy
  • Histology

Background:

  • The human urinary bladder's sensory innervation is not fully understood.
  • Pacinian corpuscles are mechanoreceptors typically found in deeper tissues.

Purpose of the Study:

  • To describe the novel finding of a Pacinian corpuscle in the human urinary bladder.
  • To characterize the structure and associations of this nerve ending.

Main Methods:

  • Histological examination of human urinary bladder tissue.
  • Microscopic analysis of encapsulated nerve structures.

Main Results:

  • A complex Pacinian corpuscle was identified within the lamina propria, adjacent to the detrusor muscle.
  • The corpuscle lacked structural evidence of directional sensitivity.

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  • Unmyelinated axons with vesicles were associated with the corpuscle's outer aspect.

    • Conclusions:

    • This represents the first report of an encapsulated nerve ending, specifically a Pacinian corpuscle, in the adult human urinary bladder lining.
    • The presence of this mechanoreceptor suggests potential roles in bladder sensation.