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The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans
M S Westerterp-Plantenga1, E M R Kovacs
1Department of Human Biology, University of Maastricht, Maastricht, The Netherlands. M.Westerterp@HB.Unimaas.nl
Objective:
Assessment of the effects of 2 weeks of daily administration of HCA on energy intake and satiety in overweight men and women.
Design:
A 6-week randomized placebo-controlled single-blinded cross-over trial.
Subjects:
consumed three times daily for 2 weeks 100 ml tomato juice (placebo) and, separated by a 2 week wash-out period, 100 ml tomato juice with 300 mg HCA.Subjects: Twelve males and 12 females (body mass index 27.5+/-2.0 kg/m(2); age 37+/-10 y).
Measurements:
After 2 weeks, 24 h energy intake (EI), appetite profile, hedonics, mood and possible change in dietary restraint were assessed in the laboratory restaurant. Prevention of degradation and bio-availability was documented.
Results:
Twenty-four-hour EI was decreased by 15-30% (P<0.05) with HCA treatment compared to placebo, without changes in the appetite profile, dietary restraint, mood, taste perception and hedonics, while body weight tended to decrease (P=0.1).
Conclusion:
HCA treatment reduced 24 h EI in humans while satiety was sustained.