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Related Experiment Videos

Extraskeletal neoplasm resembling Ewing's sarcoma.

L Angervall, F M Enzinger

    Cancer
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    This review examines 39 soft tissue sarcomas resembling Ewing's sarcoma of bone. Early detection and multimodal treatment, including surgery, radiation, and chemotherapy, are crucial for improving outcomes in these aggressive tumors.

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    Area of Science:

    • Oncology
    • Pathology
    • Skeletal System

    Background:

    • Soft tissue sarcomas can histologically mimic bone sarcomas.
    • Ewing's sarcoma is a primary bone malignancy with characteristic small, round cell morphology.

    Purpose of the Study:

    • To review the clinicopathologic features of soft tissue sarcomas indistinguishable from Ewing's sarcoma.
    • To analyze the behavior and outcomes of these rare tumors.

    Main Methods:

    • Retrospective review of 39 cases of soft tissue sarcomas.
    • Histopathologic analysis of tumor morphology.
    • Correlation of clinical data, including follow-up and survival.

    Main Results:

    • Tumors predominantly affected young adults (median age 20) in lower extremities and paravertebral regions.

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  • Histology showed small, round/ovoid cells with glycogen, sometimes with peritheliomatous pattern, necrosis, or hemorrhage.
  • Of 35 cases with follow-up, 13 survived and 22 died, often rapidly with lung and skeletal metastases.

    • Conclusions:

    • Soft tissue sarcomas histologically similar to Ewing's sarcoma are aggressive with a high metastatic potential.
    • Early diagnosis and combined modality treatment (surgery, radiation, chemotherapy) offer the best chance for cure.