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Clinicohaematological profile in chronic renal failure
V K Talwar1, H L Gupta, Shashinarayan
1Department of Medicine, Lady Hardinge Medical College and Smt. SK Hospital, New Delhi.
Summary
Chronic renal failure patients often exhibit anemia due to iron deficiency. This study observed clinicohaematological profiles and iron indices in these patients, revealing significant iron depletion.
Area of Science:
- Nephrology
- Hematology
- Clinical Biochemistry
Background:
- Chronic renal failure (CRF) is a progressive loss of kidney function.
- Patients with CRF often develop complex hematological abnormalities.
- Understanding the clinicohaematological profile is crucial for managing CRF complications.
Purpose of the Study:
- To investigate the clinicohaematological profile of patients with chronic renal failure.
- To assess bone marrow and serum iron indices in CRF patients.
- To identify the causes of anemia in this population.
Main Methods:
- A cohort of 27 CRF patients not on dialysis, hemantinics, or erythropoietin therapy was studied.
- Comprehensive biochemical and hematological investigations were performed.
- Bone marrow aspiration and serum iron indices were analyzed.
Main Results:
- Anemia was prevalent in 94% of CRF patients, frequently microcytic hypochromic (60%).
- Iron deficiency was indicated by low serum ferritin (62%) and serum iron (74%), and absent bone marrow iron stores (57%).
- Thrombocytopenia affected 52% of patients, while 32% had elevated eosinophils.
Conclusions:
- Iron deficiency is a primary cause of microcytic hypochromic anemia in CRF patients.
- Parasitic infestation was also identified as a contributing factor in 33% of cases.
- The study highlights the importance of assessing iron status in CRF management.