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Metal transporters and disease
1HHMI/Hematology, Enders 720, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA. nandrews@genetics.med.harvard.edu
Current Opinion in Chemical Biology
|June 1, 2002
Abstract:
Iron and copper are essential nutrients that must be meticulously regulated to exploit their usefulness in biological reactions while protecting against their tendency to promote formation of toxic free-radicals. This review summarizes recently described steps in the transport of these metals, and explores how defects in these steps lead to human diseases including hemochromatosis, Menkes disease and Wilson disease.