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Embryo transfer on day 3 using low versus high fluid volume.
Markus Montag1, Markus Kupka, Katrin van der Ven
1Department of Endocrinology and Reproductive Medicine, University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany. m.montag@uni-bonn.de
Summary
High fluid volume during embryo transfer significantly increases in vitro fertilization success. This study found higher pregnancy and implantation rates when using a larger fluid volume for embryo loading.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization (IVF)
Background:
- Embryo transfer technique is crucial for IVF success.
- The volume of fluid used during embryo transfer may influence outcomes.
Purpose of the Study:
- To evaluate the impact of low versus high fluid volume during embryo transfer on IVF success rates.
- To determine if fluid volume affects pregnancy and implantation rates.
Main Methods:
- Retrospective analysis of 191 embryo transfer cycles.
- Comparison of pregnancy rates between low (15-20 microliters) and high (40-50 microliters) fluid volumes.
- Statistical analysis using a two-tailed t-test.
Main Results:
- No significant differences in patient age, previous attempts, oocytes recovered, or fertilization rates were observed.
- High fluid volume (40-50 microliters) resulted in significantly higher pregnancy rates (40% vs. 23%, P=0.012) compared to low fluid volume (15-20 microliters).
- Implantation rates were also significantly higher with high fluid volume (24.4% vs. 14.7%, P=0.011).
Conclusions:
- The fluid volume used for embryo transfer on day 3 has a significant impact on pregnancy and implantation rates.
- Optimizing fluid volume during embryo transfer may improve IVF outcomes.