Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Responses to exercise in experimental hypertension.

T Baum, A T Shropshire

    Cardiovascular Research
    |November 1, 1975
    PubMed
    Summary

    Spontaneously hypertensive rats (SHR) showed minor heart rate increases during exercise stress, unlike renal hypertensive rats (RHR). Older SHR

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Finite element fracture load analysis and dark-field X-ray imaging of osteoporotic and healthy vertebrae in human lumbar spine specimens.

    BMC musculoskeletal disorders·2025
    Same author

    Epidemiology and reporting of osteoporotic vertebral fractures in patients with long-term hospital records based on routine clinical CT imaging.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
    Same author

    MR-based proton density fat fraction (PDFF) of the vertebral bone marrow differentiates between patients with and without osteoporotic vertebral fractures.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
    Same author

    X-ray-based quantitative osteoporosis imaging at the spine.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
    Same author

    Impact of brief prewarming on anesthesia-related core-temperature drop, hemodynamics, microperfusion and postoperative ventilation in cytoreductive surgery of ovarian cancer: a randomized trial.

    BMC anesthesiology·2019
    Same author

    [Diplopic images since one week and space-occupying lesion of the skull base].

    Der Radiologe·2019

    Area of Science:

    • Cardiovascular physiology
    • Hypertension research
    • Animal models of disease

    Background:

    • Spontaneously hypertensive rats (SHR) and renal hypertensive rats (RHR) are models for studying hypertension.
    • Both models exhibit exaggerated cardiovascular responses to stress.
    • Behavioral hyperexcitability is noted in SHR.

    Purpose of the Study:

    • To investigate blood pressure and heart rate responses in SHR and RHR.
    • To assess responses to a combined physical and mental stressor (treadmill exercise).
    • To determine if SHR exhibit hyper-responsiveness to exercise compared to RHR.

    Main Methods:

    • Utilized treadmill exercise as a combined physical and mental stressor.
    • Monitored blood pressure and heart rate in both SHR and RHR.
    • Compared cardiovascular responses between the two hypertensive rat models.

    Main Results:

    • SHRs displayed only slight and selective hyper-responsiveness in heart rate increases during exercise.
    • RHRs demonstrated normal cardiovascular responses to the same exercise stress.
    • The heightened sensitivity in older SHRs was linked to slightly lower resting heart rates.

    Conclusions:

    • SHRs exhibit a nuanced hyper-responsiveness to exercise stress, primarily affecting heart rate.
    • RHRs serve as a contrasting model, showing normal responses to this stressor.
    • Resting heart rate may influence the exaggerated cardiovascular sensitivity observed in aged SHRs.

    Related Experiment Videos