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Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary
Brigit A de Jong1, Rudi G J Westendorp, Joyce Eskdale
1Department of Clinical Epidemiology, University of Glasgow, Scotland, United Kingdom.
Human Immunology
|June 1, 2002
Abstract:
Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency of this polymorphism is lower among patients with primary progressive compared with patients with relapse-onset MS and control persons.