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Expeditious syntheses of two carbohydrate-linked cisplatin analogs
Yongsheng Chen1, Adam Janczuk, Xi Chen
1Department of Chemistry, Wayne State University, 373 Chemistry, Detroit, MI 48202, USA.
Carbohydrate Research
|June 1, 2002
Abstract:
The syntheses of two carbohydrate-linked cisplatin analogs, namely lacto- and alpha-Gal-cisplatin, are described. A fusion enzymatic approach was used to create the diazido-alpha-Gal trisaccharide intermediate in the synthesis of alpha-Gal-cisplatin.