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Exploration of peptidyl hydrazones as water-soluble calpain inhibitors

Masayuki Nakamura1, Jun Inoue

  • 1Research Laboratory, Senju Pharmaceutical Co., Ltd., 1-5-4 Murotani Nishiku, Kobe 651-2241, Japan. masayuki-nakamura@senju.co.jp

Bioorganic & Medicinal Chemistry Letters
|June 1, 2002
PubMed

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Hydrolysis01:15

Hydrolysis

Overview
Hydrolysis is a chemical reaction in which the addition of water breaks down a polymer into its simpler monomer units. For example, peptides break into amino acids, carbohydrates into simple sugars, and DNA into nucleotides. Enzymes often facilitate these processes.
Hydrolysis Reverses Dehydration Synthesis
Complex carbohydrates can be broken down by breaking the bonds between individual sugar units. The reaction breaks a glycosidic bond as water is added to the compound. The...