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Synthesis of oligodeoxyribonucleoside phosphorothioates using Lawesson's reagent for the sulfur transfer step
Jingyue Ju1, Charles E McKenna
1Department of Chemistry, University of Southern California, Los Angeles, CA 90089-0744, USA.
Bioorganic & Medicinal Chemistry Letters
|June 1, 2002
Abstract:
2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's reagent) efficiently converts the triphosphite intermediate used in the solid-phase synthesis of oligonucleotides into an oligodeoxyribonucleoside phosphorothioate.