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Related Experiment Videos

Subsurface cisterns in the vertebrate retina.

S K Fisher, K Goldman

    Cell and Tissue Research
    |December 18, 1975
    PubMed
    Summary

    Subsurface cisterns (SSC

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Retinal Research

    Background:

    • Subsurface cisterns (SSC's) are membrane-bound organelles within neurons.
    • Their presence and function in various species' retinal cells require further investigation.
    • Previous studies suggested their absence in glial cells.

    Purpose of the Study:

    • To identify and characterize subsurface cisterns (SSC's) in the retinas of selected mammalian and amphibian species.
    • To determine the specific retinal cell types containing SSC's.
    • To investigate the association of SSC's with other cellular structures, such as the endoplasmic reticulum.

    Main Methods:

    • Electron microscopy was used to examine retinal tissue from Western grey squirrels, ground squirrels, toads, and domestic cats.
    • Cellular localization of SSC's within different retinal neuron types was analyzed.
    • Connections between SSC's and the rough endoplasmic reticulum were examined.

    Main Results:

    • Subsurface cisterns (SSC's) were identified in retinal neurons, including amacrine, bipolar, and ganglion cells, across all studied species.
    • SSC's were observed to be connected to the rough endoplasmic reticulum.
    • Specific membrane specializations were associated with the SSC's.
    • SSC's were notably absent in Müller cells, consistent with prior findings in glial cells.

    Conclusions:

    • Subsurface cisterns (SSC's) are a conserved organelle in the retinas of diverse vertebrate species.
    • Their presence in specific neuronal subtypes suggests a role in neuronal function.
    • The association with the endoplasmic reticulum indicates potential involvement in protein synthesis or calcium storage.
    • The absence in Müller cells reinforces their classification as neuronal rather than glial organelles.

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