Related Experiment Video
Updated: Oct 1, 2026

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
Published on: July 21, 2023
Effects of quinupristin/dalfopristin on vasomotor tone in the intact peripheral microcirculation
Takaya Tsueshita1, Salil Gandhi, Israel Rubinstein
1Department of Medicine, College of Medicine, University of Illinois at Chicago, 60612-7323, USA.
Abstract:
The purpose of this study was to determine whether quinupristin/dalfopristin modulates vasomotor tone in the intact peripheral microcirculation. Using intravital microscopy, we found that superfusion of quinupristin/dalfopristin (120 mg/L) on the intact hamster cheek pouch microcirculation had no significant effects on arteriolar diameter. In addition, superfusion of quinupristin/dalfopristin (120 mg/L) had no significant effects on vasodilation evoked by bradykinin and acetylcholine, two endothelium-dependent agonists, or by vasoactive intestinal peptide, an endothelium-independent agonist, on to the cheek pouch. Collectively, these data indicate that quinupristin/dalfopristin has no significant effects on vasomotor tone in the intact peripheral microcirculation.
Related Concept Videos
Antihypertensive Drugs: Vasodilators
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Direct-Acting Cholinergic Agonists: Pharmacological Actions
