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Related Experiment Videos

A potential role for CD69 in thymocyte emigration.

Chiguang Feng1, Kenneth J Woodside, Barbara A Vance

  • 1Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.

International Immunology
|June 1, 2002
PubMed
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Constitutive expression of CD69 in mice did not impact T cell development but caused mature thymocytes to accumulate, failing to exit the thymus. This suggests CD69 regulates thymocyte export and T cell trafficking.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD69 is an early activation marker transiently expressed on T cells and thymocytes during selection.
  • The precise function of CD69, a C-type lectin-like signaling receptor, remains largely unknown.

Purpose of the Study:

  • To characterize mice with constitutive high-level surface CD69 expression on T cells.
  • To investigate the role of CD69 in T cell development, maturation, signaling, and thymocyte selection.

Main Methods:

  • Generation and analysis of transgenic mice with constitutive CD69 expression.
  • Assessment of T cell maturation, TCR signaling, thymocyte selection, and thymocyte export.

Main Results:

  • Constitutive CD69 expression did not alter T cell maturation, TCR signaling, or thymocyte selection.

Related Experiment Videos

  • Mature thymocytes accumulated in the medulla of CD69 transgenic mice and showed impaired thymic export.
  • Thymocyte retention correlated with CD69 transgene dose and surface levels.

    • Conclusions:

    • CD69 plays a potential role in regulating thymocyte export from the thymus.
    • Transient CD69 expression may control the trafficking of thymocytes and mature T cells.