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Associations between angiotensinogen gene variants and left ventricular mass and function in the HyperGEN study
Weihong Tang1, Richard B Devereux, D C Rao
1Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA.
The angiotensinogen M235T polymorphism influences left ventricular mass differently in hypertensive versus normotensive individuals. This genetic variation is linked to reduced left ventricular mass in hypertension but increased mass in normotensive states.
Area of Science:
- Cardiovascular Genetics
- Molecular Cardiology
- Hypertension Research
Background:
- The angiotensinogen M235T polymorphism is linked to hypertension and coronary heart disease.
- Its association with left ventricular (LV) mass and function requires further population-level investigation.
- This study examines two angiotensinogen gene polymorphisms (M235T and G-6A) in relation to LV mass and function.
Purpose of the Study:
- To investigate the association between angiotensinogen gene polymorphisms (M235T and G-6A) and left ventricular (LV) mass and function.
- To analyze these associations in a large population-based sample, predominantly comprising hypertensive patients.
Main Methods:
- Echocardiography (M-mode and pulsed Doppler) was performed on 605 participants.
- Angiotensinogen M235T polymorphism was analyzed using polymerase chain reaction.
- G-6A variant was measured via mass spectrophotometry.
Main Results:
- The association between angiotensinogen gene polymorphisms and LV mass differed significantly between hypertensive and normotensive groups (P <.005).
- The methionine-threonine/threonine-threonine genotype was negatively associated with LV mass and LVMI in hypertensive patients after adjustments (P <.001).
- In normotensive individuals, this genotype was associated with higher LV mass (P =.04) and LVMI (P =.14), influenced by weight but not blood pressure.
Conclusions:
- Angiotensinogen gene variation is modestly associated with LV mass in hypertensive patients, independent of covariates.
- The direction of this association is opposite in normotensive individuals, potentially due to other risk factors or medication use.
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