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Nuclear transcription factor-kappaB as a target for cancer drug development
1Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Abstract:
Nuclear factor kappa B (NF-kappaB) is a family of inducible transcription factors found virtually ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been discovered about its mechanisms of activation, its target genes, and its function in a variety of human diseases including those related to inflammation, asthma, atherosclerosis, AIDS, septic shock, arthritis, and cancer. Due to its role in a wide variety of diseases, NF-kappaB has become one of the major targets for drug development. Here, we review our current knowledge of NF-kappaB, the possible mechanisms of its activation, its potential role in cancer, and various strategies being employed to target the NF-kappaB signaling pathway for cancer drug development.
Insights
Nuclear factor kappa B (NF-kappaB) is crucial in diseases like cancer and inflammation. This review explores NF-kappaB
Area of Science:
- Molecular Biology
- Immunology
- Oncology
Background:
- Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor family.
- Its discovery in 1986 opened avenues for understanding numerous diseases.
- NF-kappaB plays a significant role in inflammation, immune responses, and various pathological conditions.
Purpose of the Study:
- To review current knowledge on NF-kappaB.
- To elucidate NF-kappaB activation mechanisms and target genes.
- To explore NF-kappaB's role in cancer and strategies for drug development.
Main Methods:
- Literature review of NF-kappaB research.
- Analysis of NF-kappaB activation pathways.
- Examination of NF-kappaB's involvement in oncogenesis.
- Survey of therapeutic strategies targeting NF-kappaB.
Main Results:
- NF-kappaB is implicated in a wide spectrum of diseases including cancer, inflammation, and infectious diseases.
- Diverse signaling pathways regulate NF-kappaB activation.
- Targeting the NF-kappaB pathway presents a promising strategy for cancer therapy.
Conclusions:
- NF-kappaB is a critical regulator of cellular processes and a key player in disease pathogenesis.
- Understanding NF-kappaB activation is vital for developing effective treatments.
- Targeting NF-kappaB signaling offers potential for novel cancer drug development.