Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multi-state models for bone marrow transplantation studies.

John P Klein1, Youyi Shu

  • 1Division of Biostatistics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

Statistical Methods in Medical Research
|June 4, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer.

The New England journal of medicine·2018
Same author

Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2016
Same author

Bioequivalence of budesonide plus formoterol (BF) Spiromax® and BF Turbohaler® (with and without charcoal block) in healthy volunteers.

International journal of clinical pharmacology and therapeutics·2015
Same author

The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2015
Same author

Center for International Blood and Marrow Transplant Research chronic graft-versus-host disease risk score predicts mortality in an independent validation cohort.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2014
Same author

Impact of Chronic Graft-versus-Host Disease on Late Relapse and Survival on 7,489 Patients after Myeloablative Allogeneic Hematopoietic Cell Transplantation for Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research·2014
Same journal

Regression analysis of misclassified current status data with potentially unknown test accuracy.

Statistical methods in medical research·2026
Same journal

Bayesian multivariate linear mixed-effects models with varied association structures.

Statistical methods in medical research·2026
Same journal

Inference about the ratio of age-standardized rates between two overlapping populations.

Statistical methods in medical research·2026
Same journal

A robust neural network with random effects for subject-specific prediction of clustered count data.

Statistical methods in medical research·2026
Same journal

A comparison of methods for designing hybrid type 2 cluster-randomized trials with continuous effectiveness and implementation endpoints.

Statistical methods in medical research·2026
Same journal

Joint analysis of longitudinal and recurrent event data: A functional regression approach with autoregressive frailty.

Statistical methods in medical research·2026
See all related articles

Bone marrow transplants improve disease treatment by addressing competing risks and recovery. This study introduces multi-state models to estimate survival probabilities and assess treatment efficiency for better patient outcomes.

Area of Science:

  • Hematology
  • Biostatistics
  • Clinical Trials

Background:

  • High-dose chemotherapy with stem cell recovery (bone marrow transplant) is a standard treatment for various diseases.
  • Bone marrow transplant studies present unique statistical challenges.
  • Effective analysis is crucial for optimizing patient care and treatment protocols.

Purpose of the Study:

  • To address common statistical problems in bone marrow transplant research.
  • To introduce methods for estimating risks, intermediate condition prevalence, and recovery.
  • To present a new measure for evaluating treatment efficiency.

Main Methods:

  • Utilized multi-state models to handle competing risks in bone marrow transplant outcomes.
  • Developed methods for estimating the prevalence of chronic graft-versus-host disease (GVHD).

Related Experiment Videos

  • Modeled the post-transplant recovery process and introduced the leukemia-free survival function.

    • Main Results:

    • Provided methods for estimating meaningful probabilities for competing risks.
    • Offered approaches to estimate the prevalence of intermediate conditions like chronic GVHD.
    • Demonstrated the application of recovery models for dynamic prognosis assessment and clinical trial design.

    Conclusions:

    • Multi-state models offer robust solutions for analyzing complex bone marrow transplant data.
    • The developed methods enhance the understanding of patient prognosis and treatment effectiveness.
    • New statistical approaches can improve the design and interpretation of bone marrow transplant studies.