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Epidemiological surveillance of staphylococcal resistance
A Giacometti1, A Fiorentini, M R Mazzoccanti
1Department of Infectious Diseases, University of Ancona, Italy.
Abstract:
The aim of our investigation was to characterize better the possible changes in staphylococcal susceptibility to some antimicrobial agents. We considered the staphylococcal strains isolated between June 1986 and June 1989 and held responsible for proved bacterial infections. In this relatively short time we observed a moderate increase in methicillin resistance. Compared with methicillin-sensitive strains, methicillin-resistant isolates showed minor susceptibility to most antimicrobial agents; nevertheless, vancomycin, teicoplanin, cefamandole, imipenem, fluoroquinolones and netilmicin, according to our results, appear at present the most reliable antistaphylococcal antibiotics.
Insights
Staphylococcal resistance to methicillin increased moderately between 1986 and 1989. Methicillin-resistant strains showed reduced susceptibility to many antibiotics, but vancomycin and fluoroquinolones remained effective options.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Staphylococcal infections pose a significant public health challenge.
- Monitoring antimicrobial susceptibility is crucial for effective treatment.
Purpose of the Study:
- To characterize changes in staphylococcal susceptibility to antimicrobial agents.
- To assess the efficacy of various antibiotics against staphylococcal strains.
Main Methods:
- Analysis of staphylococcal strains isolated between June 1986 and June 1989.
- Evaluation of antimicrobial susceptibility patterns.
Main Results:
- A moderate increase in methicillin resistance was observed.
- Methicillin-resistant isolates exhibited reduced susceptibility to most agents.
- Vancomycin, teicoplanin, cefamandole, imipenem, fluoroquinolones, and netilmicin showed reliable antistaphylococcal activity.
Conclusions:
- Methicillin resistance in staphylococci is an evolving concern.
- Certain antibiotics remain effective against resistant strains, guiding therapeutic choices.