Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Topiramate-induced nephrolithiasis.

Ramsay L Kuo1, Michael E Moran, Dennis H Kim

  • 1Clarian Health Partners, Methodist Hospital of Indiana and Indiana University School of Medicine, Indianapolis, Indiana, USA. rkuo@iupui.edu

Journal of Endourology
|June 4, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of a Renal Papillary Grading System: Comparison of Patients Forming Calcium Oxalate and Apatite Stones.

Journal of endourology·2026
Same author

Scanning electron microscopy and energy dispersive spectroscopy of Randall's plaque stones: an unexpected finding of monosodium urate crystals.

Urolithiasis·2025
Same author

A biophysical approach to studying N-terminal cysteine oxidase substrate preferences.

Methods in enzymology·2025
Same author

The Potential of Flight Simulation to Support Pilot Training for Mountain Helicopter Emergency Medical Services.

Air medical journal·2025
Same author

Correspondence.

Urolithiasis·2025
Same author

Molecular Pharmacology of the Antibiotic Fosfomycin, an Inhibitor of Peptidoglycan Biosynthesis.

Biochemistry·2025

Topiramate, an antiepileptic drug, can cause kidney stones by affecting urine pH and leading to metabolic acidosis. Urologists should monitor patients for this potential side effect.

Area of Science:

  • Nephrology
  • Pharmacology
  • Urology

Background:

  • Topiramate is an effective antiepileptic medication increasingly prescribed for refractory seizures.
  • Understanding its metabolic and renal effects is crucial for patient management.

Observation:

  • Topiramate inhibits carbonic anhydrase, potentially causing metabolic acidosis.
  • This can lead to a distal tubular acidification defect, impairing urine pH regulation.

Findings:

  • These combined effects can promote the formation of calcium phosphate nephrolithiasis (kidney stones).
  • This report details the first two cases of topiramate-induced nephrolithiasis in urologic literature.

Implications:

  • Urologists must be aware of topiramate's potential to cause kidney stones.

Related Experiment Videos

  • Monitoring urine pH and metabolic parameters may be necessary in patients taking topiramate.