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Validation of the Cardiovascular Limitations and Symptoms Profile (CLASP) in chronic stable angina
Robert J P Lewin1, David R Thompson, Colin R Martin
1Department of Health Sciences, University of York, York, UK.
Insights
The Cardiovascular Limitations and Symptoms Profile (CLASP) is a reliable and valid tool for assessing health-related quality of life in patients with chronic stable angina.
Area of Science:
- Cardiology
- Health Outcomes Research
- Psychometrics
Background:
- Chronic stable angina significantly impacts patients' quality of life.
- Accurate assessment tools are crucial for evaluating interventions and patient well-being.
Purpose of the Study:
- To establish the reliability, validity, and sensitivity of the Cardiovascular Limitations and Symptoms Profile (CLASP).
- To evaluate CLASP's utility in patients with chronic stable angina.
Main Methods:
- 226 patients with angina were randomized into three groups: angina management program, routine care, or exercise therapy.
- Patients completed CLASP at baseline and 10 weeks, alongside SIP, HADS, and SPQ questionnaires.
Main Results:
- CLASP demonstrated significant correlations with angina episodes, treadmill time, and quality of life measures (SIP, SPQ).
- The CLASP subscales showed strong correlations with corresponding Sickness Impact Profile subscales, confirming validity.
Conclusions:
- CLASP is a reliable, valid, and sensitive measure for assessing health-related quality of life in chronic stable angina patients.
- Further validation in diverse cardiac patient groups (e.g., heart failure, post-MI) is recommended.
Purpose:
This study aimed to establish the reliability, validity, and sensitivity of the Cardiovascular Limitations and Symptoms Profile (CLASP) in a group of patients with chronic stable angina.
Methods:
After 226 patients with angina had been recruited, they were randomly allocated to one of three groups: a 10-week hospital-based angina management program (n = 75; men = 56; age = 60 +/- 8 years), routine care (n = 74; men = 52; age = 61 +/- 7 years), and exercise therapy (n = 77; men = 60; age = 60 +/- 7 years). All the patients were assessed with CLASP on two occasions: at baseline and at 10 weeks. The Sickness Impact Profile (SIP), the Hospital Anxiety and Depression Scale (HADS), and the Sleep Problems Questionnaire (SPQ) also were administered at the same time.
Results:
Significant positive correlations between the actual number of angina episodes and the CLASP angina subscale scores (r =.60, P <.001) were observed. The CLASP subscale scores for shortness of breath (r = -.36; P <.001) and ankle swelling (r = -.24; P <.001) were significantly correlated with the total treadmill time. The CLASP tiredness subscale score showed a significant positive correlation with the SPQ score (r =.48; P <.001). The CLASP subscale scores were significantly correlated with their corresponding SIP subscale scores: the tiredness score with the sleep and rest score (r =.49; P <.001), the social and leisure score with the recreation and pastimes score (r =.41; P <.001), the home score with the home management score (r =.45; P <.001), and the mobility score with the mobility (r =.37; P <.001) and total treadmill time scores (r = -.49; P <.001).
Conclusions:
The findings show CLASP to be a reliable, valid, sensitive measure of health-related quality of life in patients with chronic stable angina. Before it can be recommended for all patients with heart disorders, similar data will be required from other diagnostic groups such as patients with heart failure or those who have sustained an acute myocardial infarction.