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Organotypic Cerebellar Cultures: Apoptotic Challenges and Detection
Published on: May 17, 2011
IAP proteins: blocking the road to death's door
Guy S Salvesen1, Colin S Duckett
1Program in Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Nature Reviews. Molecular Cell Biology
|June 4, 2002
Summary
The inhibitor of apoptosis (IAP) gene family encodes proteins that regulate cell death and other cellular functions. This review covers IAP proteins, their binding factors, and their regulatory mechanisms.
Area of Science:
- Cellular Biology
- Molecular Biology
- Genetics
Background:
- The inhibitor of apoptosis (IAP) gene family has emerged as critical regulators of cellular processes.
- These proteins are known for their role in suppressing apoptotic cell death.
- Emerging evidence highlights their involvement in diverse cellular functions beyond apoptosis.
Purpose of the Study:
- To provide a comprehensive review of the inhibitor of apoptosis (IAP) gene family.
- To elucidate the functional and structural properties of IAP proteins.
- To discuss recently identified IAP-binding factors that modulate IAP activity.
Main Methods:
- Literature review of functional and structural studies on IAP proteins.
- Analysis of research on IAP-binding factors and their regulatory roles.
- Synthesis of current knowledge on IAP family members.
Main Results:
- IAP proteins share structural similarities and possess anti-apoptotic functions.
- The IAP family is implicated in a growing list of cellular processes.
- Several novel IAP-binding factors have been identified that regulate IAP function.
Conclusions:
- The IAP gene family represents a crucial group of proteins with diverse cellular roles.
- Understanding IAP proteins and their regulators is vital for comprehending cell fate.
- Further research into IAP-binding factors will uncover new regulatory pathways.
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